傅滨,教授,博士生导师,主要研究方向为农药创制和有机合成,致力于杂环化学应用于新农药创制与不对称合成,先后承担国家化学理科基地“有机化学”和核心课程“有机化学及实验”教学工作。已指导毕业硕士13名和博士8名。现指导博士生3名,硕士生2名。先后6次获得 “校级百篇优秀本科毕业设计”优秀指导教师,3次获得 “国家大学生创新性实验计划”优秀指导教师。2012年获“宝钢优秀教师奖”。 主持国家自然基金、主持和参加“十一五”、“十二五”科技支撑计划课题和“十三五”国家重点研发计划、以及企业合作课题多项,具有丰富的农药分子设计及有机合成方面的经验。在国内外著名期刊“Chem.Commun.”;“JOC”;”Org.Chem.Front.”;”Tetrahedron”等发表文章80余篇,被引用千余次,以第一发明人申请中国发明专利12项,获授权10项。 本实验室是优秀学生的培养基地,先后推荐二十多名本科生和研究生保送到美国、港大、北大、清华、上海有机所及中科院化学所等国内外著名科研机构。在本实验室进行学习的研究生和本科生先后有12人赴美留学,其中博士刘磊在美国马里兰大学做博士后期间,在国际顶级期刊“Science, 2021,374,432.”发表文章。希望对有机合成,、农药合成或材料合成感兴趣的同学加入进来,脚踏实地,砥砺奋进,实现梦想。 代表性文章 1. Wenjie Lan, Rong-chao Lei, Jiayu Luo, Zhaohai Qin, Bin Fu,* and Lei Xie* A Facile Approach to Benzosultam-fused 4-Imidazolidinone Derivatives from N-Sulfonyl Ketimine and α-Halogenated Hydroxamates, ChemistrySelect 2022, 7, 3670–3675. 2. Wenjuan Wu , Changsheng Li , Desheng Liu , Jiawen Ji , Jianhui Zhu , Huizhe Lu , Bin Fu *, Yongqiang Ma, Ultrasensitive antibody production strategy based on hapten property for simultaneous immunoassay, Food Chemistry 2022, 395, 133565. 3. Jia-yu Luo, Peng-fei Chenzhang, Wenjie Lan, Jia-qi Li, Zhaohai Qin and Bin Fu* A Highly Enantioselective Approach to Hydrocarbazole Derivatives Catalyzed by Diphenylmethylidene Bis(oxazoline)-Ni(II) Complexes, ChemistrySelect 2021, 6, 6890–6894. 4. Xuan Yu, Wenjie Lan, Jiaqi Li, Hui Bai, Zhaohai Qin and Bin Fu* Enantioselective one-pot synthesis of 4H-chromene derivatives catalyzed by a chiral Ni(II) complex, RSC Adv. 2020, 10, 44437-44441. 5. Xuan Yu, Hui Bai, Dong Wang, Zhaohai Qin, Jia-Qi Li* and Bin Fu* A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(II)-catalyzed enantioselective Michael addition. RSC Adv. 2018, 8, 19402-19408. 6. Lei Xie, Hongli Ma, Jiaqi Li, Yuan Yu, Zhaohai Qin and Bin Fu*. Ni(II)-Catalyzed enantioselective Mukaiyama-Mannich reaction between silyl enol ethers and cyclic N-sulfonyl α-ketiminoesters, Org. Chem. Front. 2017, 4, 1858–1862 7. Hongli Ma, Lei Xie, Zhenhua Zhang, Lin-gang Wu, Bin Fu,* and Zhaohai Qin* Enantioselective Conjugate Addition of 2‑Acetyl Azaarenes toβ,β‑DisubstitutedNitroalkene for the Construction of All-Carbon Quaternary Stereocenters, J. Org. Chem. 2017, 82, 7353−7362. 8. Hongli Ma; Xiaojing Yan, Yumei Xiao, DekaiYuan, Zhenhua Zhang, Bin Fu,* HuizhuYuan, Synthesis and fungicidal activities of azaindolyl thiazoline compounds, Chin. J. Org. Chem. 2016, 36, 158-164. 9. Lei Xie, Xuan Yu, Jiaqi Li, Zhenhua Zhang, Zhaohai Qin, Bin Fu,* Nickel(II)-Catalyzed Enantioselective 1,3-Dipolar Cycloaddition of Nitrones with α,β-Unsaturated Acylcarboxylates, Eur. J. Org. Chem. 2017, 657–661. 10. Lei Xie, Hui Bai, Jiaqi Li, Xuan Yu, Bin Fu,* Cu(II)-catalyzed enantioselective 1,3-dipolar cycloaddition of nitrones with a, b-unsaturated acyl phosphonates, Tetrahedron 2017, 73, 2923-2930. 11. Xuhe Hou, Hongli Ma, Zhenhua Zhang, Zhaohai Qin, Lei Xie, Zhaohai Qin, Bin Fu* An efficient approach for the construction of trifluoromethylated all-carbon quaternary stereocenters: enantioselective Ni(II)-catalyzed Michael addition of 2-acetyl azaarene to disubstituted nitroalkenes, Chem. Commun., 2016, 52, 1470--1473. 12. Hongli Ma; Lei Xie, Zhenhua Zhang, Jiaqi Li, Zhaohai Qin, Bin Fu, Enantioselective Copper(II)-Catalyzed Conjugate Addition of Indoles to β-Substituted Unsaturated Acyl Phosphonates Adv. Synth. Catal. 2016, 358, 1011–1016. 13. Han Sun, BohanYin, Hongli Ma, Huizhu Yuan, Bin Fu,* Li Bing Liu,* Synthesis of a novel quinoline skeleton introduced cationic polyfluorene derivative for multimodal antimicrobial application, ACS Appl. Mater. Interfaces 2015, 7, 25390−25395. 14. Wang, X.; Xie, Z., Fu, B.*; Li, N.; Wang, M.; Ma, Y.; Y. Xu, and Qin, Zh.-H.* Studies on synthesis and biological activity of oxidative aglafolin derivatives, J. Heteo. Chem. 2014, 51, 1430-1434. 15. Hou, X.-H.; Ma, H.-L.; Zhang, Zh.-H.; Xie, L. Qin, Zh.-H.; Fu, B.* An efficient approach for the construction of trifluoromethylated all-carbon quaternary stereocenters: enantioselective Ni(II)-catalyzed Michael addition of 2-acetyl azaarene to disubstituted nitroalkenes, Chem. Commun., 2016, 52, 1470--1473. 16. Sun, H.; Yin, B.-H.; Ma, H.-L.; Yuan, H.-X.; Fu, B.*; Liu, L.-B.* Synthesis of a novel quinoline skeleton introduced cationic polyfluorene derivative for multimodal antimicrobial application, ACS Appl. Mater. Interfaces 2015, 7, 25390. 17. Ma, H.-L.; Li, J.-Q.; Sun, L.; Hou, X.-H.; Zhang, Zh.-H.; Fu, B.* Heteroarylidene-tethered bis(oxazoline) copper complexes catalyzed cascade reaction involving asymmetric F-C alkylation/N-hemiacetalization of indoles with unsaturated ketoester, Tetrahedron, 2015,71, 3625. 18. Liu, L.; Ma, H.-L.; Xiao, Y.-M.; Du, F.-P.; Li, N.; Qin, Zh.-H.; Fu, B.* Highly enantioselective F–C alkylation of indoles and pyrrole with β,γ-unsaturated α-ketoesters catalyzed by heteroarylidene-tethered bis(oxazoline) copper complexes, Chem.Commun. 2012, 48, 9281. 授权代表性发明专利 1. 一种喹诺酮基噁唑烷酮类化合物及其制备方法和用途,傅滨,白慧,兰文捷,陈张鹏飞,覃兆海,授权号 ZL202110372743.1。 2. 一种含三氟甲基的吡啶基吡咯啉化合物及制备方法和应用, 傅滨,谢磊,武林刚,张振华,李佳奇,覃兆海,授权号ZL 201610622540.2。 3. 含全碳季碳手性中心和氮芳香杂环的α,α-双取代-β-硝基酯类化合物及其衍生物的制备,傅滨,麻红利,谢磊,张振华,李佳奇,授权号,ZL201610390624.8。 4. 一类氮杂吲哚骨架噻唑啉衍生物及其制备方法与应用, 傅滨,麻红利,侯绪和,张振华,覃兆海, 申请号201410088294.8, 授权号 ZL201410088294.8。 5. 一种不对称合成含手性季碳中心的苯并内磺酰胺类化合物的方法 傅滨,谢磊,余轩,白慧,李佳奇,授权号, ZL201611117373.2。 6.一种氨基噻唑啉手性配体及其制备方法和应用, 傅滨,麻红利,白慧,谢磊,张振华,覃兆海 申请号201610932167.0,授权号,ZL201610932167.0 7. 一种α-二苯基膦取代的α,β-不饱和羧酸酯化合物及其制备与应用, 傅滨, 谢磊, 麻红利, 张振华,覃兆海 申请号 201410820320.1,授权号 ZL201410820320.1。 8. 一种不对称合成含三氟甲基手性季碳化合物的方法,傅滨,侯绪和,麻红利,张振华,覃兆海, 申请号201510085018.0,授权号ZL 201510085018.0。 9. 芳杂环甲叉双噁唑啉化合物的制备及用途,申请号200910087763.3, 授权号,ZL200910087763.3,傅滨,孙燕锦,刘磊,喻艳波,郑中博。 10. 2,4-二取代噻唑啉衍生物及其制备方法与应用,傅滨,程学明,肖玉梅,李舟,郑中博。授权号,ZL200810104850.0。
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