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傅 滨
性 别: 学 位: 博士
职 称: 教授 所属系别: 应用化学系
E -- mail : fubinchem@cau.edu.cn
 

 

傅滨,教授,博士生导师,主要研究方向为农药创制和不对称合成,致力于杂环化学应用于新农药创制与不对称合成,同时承担国家化学理科基地《有机化学》教学工作。已指导毕业硕士6名和博士5名。现指导博士生3名,硕士生2名。先后6次获得 “校级百篇优秀本科毕业设计”优秀指导教师称号,3次获得 “国家大学生创新性实验计划”优秀指导教师称号。2012年获“宝钢优秀教师奖”。先后指导和推荐十几名本科生保送到港大、北大、清华、上海有机所及中科院化学所等国内外著名科研机构。

 

主持科研项目:

1、主持国家自然基金“基于NQNO的细胞色素c还原酶抑制剂的设计、合成与构效关系研究”,No. 21172255,(2012.1-2015.12)。

2主持国家“十一五”科技支撑计划“三噻唑啉化合物的合成与杀菌活性研究”课题,2006BAE01A01,(2006.10~2008.10),15万。

3主持国家“十一五”科技支撑计划“唑啉类核心物质的研究与开发”,20098AK61804,(2010.82012.3),12万。

4、主持国家“十二五”科技支撑计划“2-取代芳杂环基噻唑啉衍生物的合成与活性研究”(2011.32015.3),16万。

5、主持教育部课题“氨基噻唑啉化合物的合成与催化性能研究”,2010JS302010.9-2011.98

6主持农业部重点实验室重点基金课题“1,3-噻唑啉衍生物的合成与活性研究”,2010.52011.5

 

已发表SCI文章50余篇。近年来代表性文章:

1.Ni(II)-Catalyzed enantioselective Mukaiyama-Mannich reaction between silyl enol ethers

 and cyclic N-sulfonyl α-ketiminoesters,Org. Chem. Front., 2017, 4, 1858–1862(IF=4.95)

2. Enantioselective Conjugate Addition of 2‑Acetyl Azaarenes toβ,β‑Disubstituted Nitroalkene for the Construction of All-Carbon Quaternary Stereocenters,J. Org. Chem. 2017, 82, 7353−7362(IF=4.85)

3.Nickel(II)-Catalyzed Enantioselective 1,3-Dipolar Cycloaddition of Nitrones with α,β-Unsaturated   

 Acylcarboxylates,Eur. J. Org. Chem. 2017, 657-661(IF= 3.0)

4.Cu(II)-catalyzed enantioselective 1,3-dipolar cycloaddition of nitrones with a, b-unsaturated acyl phosphonates,

   Tetrahedron,2017,73,2923-2930.(IF=2.62)

5. An efficient approach for the construction of trifluoromethylated all-carbon quaternary stereocenters: 

    enantioselective Ni(II)-catalyzed Michael addition of 2-acetyl azaarene to disubstituted nitroalkenes,

    Chem. Commun., 2016, 52, 1470--1473.(IF = 6.8)

6.Enantioselective Copper(II)-Catalyzed Conjugate Addition of Indoles to beta-Substituted Unsaturated Acyl Phosphonates,

     Adv. Synth. Catal. 2016, 358, 1011 –1016.(IF = 6.3)

7. Synthesis and Fungicidal Activities of Azaindolyl Thiazoline Compounds, Chin. J. Org. Chem. 2016, 36, 158-164

8. Synthesis of a Novel Quinoline Skeleton Introduced Cationic Polyfluorene Derivative for Multimodal

    Antimicrobial Application, ACS Appl. Mater. Interfaces 2015, 7, 25390−25395.(IF = 7.1)

9. Heteroarylidene-tethered bis(oxazoline) copper complexes catalyzed cascade reaction involving asymmetric F-C 

   alkylation/N-hemiacetalization of indoles with unsaturated ketoester, Tetrahedron, 2015,71, 3625-3631.(IF=2.8)

10.Highly enantioselective F–C alkylation of indoles and pyrrole with β,γ-unsaturated α-ketoesters catalyzed

    by heteroarylidene-tethered bis(oxazoline) copper complexes, Chem.Commun. 2012, 48, 9281-9283(IF=6.8)

11. Malonate-type bis(oxazoline) ligands with sp2 hybridized bridge carbon: synthesis and application in Friedele-Crafts alkylation and allylic alkylation, Tetrahedron 2011,67, 9602-9608(.(IF = 2.8)

12. Synthesis of heteroarylidene malonate derived bis(thiazolines) and their application in F-C alkylation,

 Tetrahedron: Asymmetry, 2011, 22, 550-557.(IF = 2.6).

13. Highly enantioselective Friedel–Crafts reaction of indoles with N-sulfonyl aldimines catalyzed by hetero-

arylidene malonate-type bis(oxazoline) copper(II) complexes, Tetrahedron: Asymmetry, 2011,22, 1874-1878.

14. Highly enantioselective Friedel-Crafts reaction of indole with alkylidene malonate,Advanced Synthesis & Catalysis, 2009,351, 3113-3117.(IF = 5.66)

15. Synthesis of novel C3 symmetric tris-thiazoline ligands and their application in the allylic oxidation,

   Tetrahedron: Asymmetry:2008, 19, 2159-2163..(IF = 2.6)

16. Synthesis of novel fluoren-9-ylidene malonate derived bis(oxazoline) ligands and their application in

   Friedel-Crafts reaction, Molecules, 2010,15, 8582-8592.

17. Synthesis and Fungicidal Activity of 1,3-Thiazoline Derivatives Bearing Nitrophenyl Group on the 2-Position,

   J. Heterocyclic Chemistry, 2011, 48, 729-732.

18. Synthesis and Biological Activity of 2-Indolyl containing halogenated indolyl moiety,

      Phos. Sulf. Silicon and Rela.  2011, 186, 1790-1800.

19. A convenient one-pot synthesis of arene-centered tris(tiazoline), Heterocycles, 2009, 79, 1031-1039.

 

 

申请专利:

1、芳杂环甲叉双噁唑啉化合物的制备及用途,申请号 200910087763.3, 授权号ZL200910087763.3

2 24-二取代噻唑啉衍生物及其制备方法与应用,申请号200810104850.0, 授权号 ZL200810104850.0

32-取代芳杂环基-1,3-噻唑啉衍生物及其制备方法和应用,申请号 201010250887.1

4手性二苯并环庚二烯双噁唑啉配体化合物及其制备与应用,申请号:授权公告号 CN 100364981C

 


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