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学术报告 Total Synthesis of Diterpene Natural Products
报  告  人:Prof. Peter Metz (Faculty of Chemistry and Food Chemistry, Technische Universität Dresden, Germany)
时        间:2019年7月16日 上午10点
地        点:西校区理学楼341
主办单位:应用化学系
联系人:刘尚钟 钟江春
联系方式: 010-62731356

      Peter Metz was born in 1953 in Wuppertal, Germany. He studied chemistry at the University of Münster, where he received his Diploma (1979) and PhD degree (1983) under the guidance of H. J. Schäfer. After a postdoctoral research stay with B. M. Trost (1983-1984; University of Wisconsin-Madison), he returned to Münster and completed his habilitation in 1991. Following temporary full professorships at the University of Hamburg (1992-1993), the University of Kiel (1994) and the TU Dresden (1996), he became a full professor at the TU Dresden (1997). His research interest covers the total synthesis of biologically active natural products and their analogs, as well as the development of novel methods and strategies for stereoselective synthesis.

E-mail: peter.metz@chemie.tu-dresden.de

Internet: https://tu-dresden.de/mn/chemie/oc/oc1/

The Representing Publications

      1.Kessberg A, Luebken T, Metz P. Enantioselective total synthesis of natural isoflavans: Asymmetric transfer hydrogenation/deoxygenation of isoflavanones with dynamic kinetic resolution. Org. Lett. 2018, 20

      3006-3009.

2.Wang Y, Metz P. Total synthesis of the neoclerodane diterpene salvinorin a via an intramolecular diels-alder strategy. Org. Lett. 2018, 20, 3418-3421.

3.Wang Y, Jaeger A, Gruner M, Luebken T, Metz P. Enantioselective total synthesis of 3β-hydroxy-7β-kemp-8(9)-en-6-one, a diterpene isolated from higher termites. Angew. Chem., Int. Ed. 2017, 56, 15861-15865.

4.Qin T, Metz P. Enantioselective synthesis of isoflavanones by catalytic dynamic kinetic resolution. Org. Lett. 2017, 19, 2981-2984.

5.Kessberg A, Metz P. Utilizing an o-quinone methide in asymmetric transfer hydrogenation: Enantioselective synthesis of brosimine A, brosimine B, and brosimacutin L. Angew. Chem., Int. Ed. 2016, 55, 1160-1163.

6. Kessberg A, Metz P. Enantioselective synthesis of 2'- and 3'-substituted natural flavans by domino asymmetric transfer hydrogenation/deoxygenation. Org. Lett. 2016, 18, 6500-6503.

7. Lemke M-K, Schwab P, Fischer P. Tischer S, Witt M, Noehringer L, Rogachev V, Jaeger A, Kataeva O, Froehlich R, et al. A practical access to highly enantiomerically pure flavanones by catalytic asymmetric transfer hydrogenation. Angew. Chem., Int. Ed. 2013, 52, 11651-11655.

8.Schubert M, Metz P. Enantioselective total synthesis of the diterpenes kempene-2, kempene-1, and 3-epi-kempene-1 from the defense secretion of higher termites. Angew. Chem., Int. Ed. 2011, 50, 2954-2956.

9.Zahel M, Kessberg A, Metz P: A short enantioselective total synthesis of (-)-englerin A. Angew. Chem., Int. Ed. 2013, 52, 5390-5392.

10.  Hennig R, Metz P. Enantioselective synthesis of 4-desmethyl-3α-hydroxy-15- rippertene. Angew. Chem., Int. Ed. 2009, 48, 1157-1159.

 

 
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