教育经历：

1993-1997     中国农业大学应用化学系, 理学学士

1997-2002     中国农业大学应用化学系, 理学博士

工作经历：

2002-2004     中国科学院上海有机化学研究所, 博士后

2004-2006     德国马普所(Muelheim), Research Associate

2006-2008     美国加州大学洛杉矶分校, 博士后

2008-2009     美国伊利诺伊大学厄本那-香槟分校, Research Associate

2009-2010     美国加州大学洛杉矶分校, 访问学者

2010-2011     中国农业大学理学院应用化学系，副教授

2012-至今     中国农业大学理学院应用化学系，教授

研究方向及兴趣：

1.研究金属和有机小分子催化的环加成及环化反应，特别是基于1,3-偶极子的高效、高选择性环加成反应，发展高效的选择性合成方法，并利用手性金属催化剂和手性有机小分子催化剂发展高效和高选择性的不对称合成新方法，研究这些方法在杂环分子及复杂生物活性分子合成中的应用。

2.合成具有重要生物活性的杂环化合物及天然产物，用于杀虫剂、除草剂、杀菌剂及植物生长调节剂等的研究，开展新农药创制工作。

3.研究农药的创新合成工艺。

研究及教学工作简介：

以新农药创制和农药绿色合成为导向，以构建多样性杂环小分子库为目标，研究基于两性离子的环加成及环化反应和多样性导向合成，发展高选择性、经济、高效的合成杂环化合物的方法学，构建具有骨架结构多样性、官能团多样性、立体化学多样性的杂环化合物库，开展生物活性研究。已在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、ACS Catal.、Chem. Sci.、Chem. Rev.等刊物上发表论文 120 余篇，授权5项中国发明专利。研究成果被Synfact、Organic Chemistry Portal 和 《有机化学》 等作为亮点评述。近5年被他引2000余次，先后有7篇论文入选ESI“高被引论文”，1篇论文入选ESI“热点论文”，单篇最高他引160 余次。

长期主讲本科生课程《有机化学B》，已培养10余名研究生，其中多人次获得国家奖学金，三人次的论文被评为中国农业大学校级优秀硕士或博士学位论文。多次获得本科生“百篇优秀毕业论文（设计）”和“国家大学生创新性实验计划”项目优秀指导教师奖，所培养本科生六人次获得校级优秀毕业论文。

近年发表的论文及著作：

1. Biming Mao, Honglei Liu, Zhengyang Yan, Yi Xu, Jiaqing Xu, Wei Wang, Yongjun Wu, Hongchao Guo,* “Palladium-Catalyzed Asymmetric [4+2] Cycloaddition of 2-Methylidenetrimethylene Carbonate with Alkenes: Access to Chiral Tetrahydropyran-Fused Spirocyclic Scaffolds”, Angew. Chem. Int. Ed. 2020, 59, DOI: 10.1002/anie.202002765.

2. Yunyao Zhu, Jiangjiexing Wu, Lijun Han, Xiaoyu Wang, Wei Li, Hongchao Guo,* Hui Wei,* “Nanozyme Sensor Arrays Based on Heteroatom-Doped Graphene for Detecting Pesticides”. Anal. Chem. 2020, 92,7444−7452.

3. Wangyu Shi, Biming Mao, Jiaqing Xu, Qijun Wang, Wei Wang, Yongjun Wu, Xuefeng Li, Hongchao Guo,* Phosphine-Catalyzed Cascade Michael Addition/[4+2] Cycloaddition Reaction of Allenoates and 2-Arylidene-1,3-indanediones, Org. Lett. 2020, 22, 2675−2680.

4. Biming Mao, Junya Zhang, Yi Xu, Zhengyang Yan, Wei Wang, Yongjun Wu, Changqing Sun, Bing Zheng, and Hongchao Guo,* “Palladium-catalyzed [3+2] annulation of allenyl carbinol acetates with C,N-cyclic azomethine imines”, Chem. Commun. 2019, 55, 12841−12844.

5. Chang Wang, Yuehua Chen, Jingyu Li, Leijie Zhou, Bo Wang, Yumei Xiao, and Hongchao Guo,* “Phosphine-Catalyzed Asymmetric Cycloaddition Reaction of Diazenes: Enantioselective Synthesis of Chiral Dihydropyrazoles”, Org. Lett. 2019, 21, 7519−7523.

6. Leijie Zhou, Yuan Zeng, Xing Gao, Qijun Wang, Chang Wang, Bo Wang, Wei Wang, Yongjun Wu, Bing Zheng,* and Hongchao Guo,* “A chiral squaramide-catalyzed asymmetric dearomative tandem annulation reaction through a kinetic resolution of MBH alcohols: highly enantioselective synthesis of three-dimensional heterocyclic compounds”, Chem. Commun. 2019, 55, 10464−10467.

7. Leijie Zhou, Chunhao Yuan, Yuan Zeng, Qijun Wang, Chang Wang, Min Liu, Wei Wang, Yongjun Wu, Bing Zheng,* and Hongchao Guo,* “Direct Activation of Unmodified Morita-Baylis-Hillman Alcohols through Phosphine Catalysis for Rapid Construction of Three-Dimensional Heterocyclic Compounds”, Org. Lett. 2019, 21, 4882−4886.

8. Biming Mao, Yi Xu, Yuehua Chen, Jipan Dong, Junya Zhang, Kejia Gu, Bing Zheng and Hongchao Guo,* “Palladium-Catalyzed Asymmetric Tandem [3+2] Cycloaddition/Allylation Reaction of Methylene-Trimethylenemethane: Access to Chiral Tricyclic Dinitrogen-Fused Heterocycles”, Org. Lett. 2019, 21, 4424−4427.

9. Xing Gao, Miaoren Xia, Chunhao Yuan, Leijie Zhou, Wei Sun, Cheng Li, Bo Wu, Dongyu Zhu, Cheng Zhang, Bing Zheng, Dongqi Wang, Hongchao Guo,* “Enantioselective Synthesis of Chiral Medium-Sized Cyclic Compounds via Tandem Cycloaddition/Cope Rearrangement Strategy”, ACS Catal. 2019, 9, 1645−1654.

10. Wangyu Shi, Leijie Zhou, Biming Mao, Qijun Wang, Chang Wang, Cheng Zhang, Xuefeng Li, Yumei Xiao,* and Hongchao Guo,* “Phosphine-Catalyzed [3+2] Annulation of β-Sulfonamido-Substituted Enones with Sulfamate-Derived Cyclic Imines”, J. Org. Chem. 2019, 84, 679−686.

11. Hongchao Guo,* Yi Chiao Fan, Zhanhu Sun, Yang Wu, and Ohyun Kwon,* “Phosphine Organocatalysis”, Chem. Rev. 2018, 118, 10049−10293.

12. Leijie Zhou, Chang Wang, Chunhao Yuan, Honglei Liu, Cheng Zhang, and Hongchao Guo,* “Phosphine-Catalyzed [3+2] Annulation of 2-Hydroxy-1,4-Naphthaquinones and Allenoate: An Allene-Alkene [3+2] Annulation Mechanism Involving Consecutive γ-Addition–Aldol Reaction”, Org. Lett. 2018, 20, 6591−6595.

13. Feng Jiang, Xinping Feng, Rou Wang, Xing Gao, Hao Jia, Yumei Xiao, Cheng Zhang,* and Hongchao Guo,* “Asymmetric [3+3] Annulation of Copper−Allenylidenes with Pyrazolones: Synthesis of Chiral 1,4-Dihydropyrano[2,3-c]pyrazoles”, Org. Lett. 2018, 20, 5278–5281.

14. Zhenzhen Gao, Chang Wang, LeijieZhou, Chunhao Yuan, Yumei Xiao, Hongchao Guo,* “Phosphine-Catalyzed [8+2]-Annulation of Heptafulvenes with Allenoates and Its Asymmetric Variant: Construction of Bicyclo[5.3.0]decane Scaffold”, Org. Lett. 2018, 20, 4302–4305.

15. Hao Jia, Zhenyan Guo, Honglei Liu, Biming Mao, Xueyan Shi,* Hongchao Guo,* “Tandem Nucleophilic Addition–Cycloaddition of Arynes with α-Iminoesters: Two Concurrent Pathways to Imidazolidines”, Chem. Commun. 2018, 54, 7050–7053.

16. Honglei Liu, Hao Jia, Wangyu Shi, Chang Wang, Cheng Zhang, Hongchao Guo,* “Nickel (II)-Catalyzed [8+3] Cycloaddition of 2-Aryl-N-tosyl-aziridines with Tropone”, Org. Lett. 2018, 20, 3570–3573.

17. Zhenyan Guo, Hao Jia, Honglei Liu, Qijun Wang, Jiaxing Huang, Hongchao Guo,* “A [4+3] Annulation Reaction of aza-o-Quinone Methides with Arylcarbohydrazonoyl Chlorides for Synthesis of 2,3-Dihydro-1H-benzo[e][1,2,4]triazepines”, Org. Lett. 2018, 20, 2939–2943.

18. Chang Wang, Yan Li, Yang Wu, Qijun Wang, Wangyu Shi, Chunhao Yuan, Leijie Zhou, Yumei Xiao, Hongchao Guo,* “Enantioselective Construction of Tetrahydroquinazoline Motifs via Palladium-Catalyzed [4+2] Cycloaddition of Vinyl Benzoxazinones with Sulfamate-Derived Cyclic Imines”, Org. Lett. 2018, 20, 2880–2883.

19. Chunhao Yuan, Yang Wu, Dongqi Wang, Zhenhua Zhang, Chang Wang, Leijie Zhou, Cheng Zhang, Baoan Song, Hongchao Guo,* “Formal [5+3] Cycloaddition of Zwitterionic Allylpalladium Intermediates with Azomethine Imines for Construction of N,O-Containing Eight-Membered Heterocycles”, Adv. Synth. Catal. 2018, 360, 652–658.

20. Leijie Zhou, Chunhao Yuan, Yuan Zeng, Honglei Liu, Chang Wang, Xing Gao, Qijun Wang, Cheng Zhang, Hongchao Guo,* “Phosphine-Catalyzed [5+1] Annulation of δ-Sulfonamido-Substituted Enones with N-Sulfonylimines: A Facile Synthesis of Tetrahydropyridines”, Chem. Sci. 2018, 9, 1831–1835.

21. Chang Wang, Zhenzhen Gao, Leijie Zhou, Qijun Wang, Yang Wu, Chunhao Yuan, Jianning Liao, Yumei Xiao, Hongchao Guo,* “Multifunctional Chiral Phosphine-Catalyzed [3+2] Annulation of Morita–Baylis–Hillman Carbonates with Cyclopentenones: Asymmetric Synthesis of 4-oxo-Hexahydropentalenes”, Chem. Commun. 2018, 54, 279–282.

22. Biming Mao, Wangyu Shi, Jianning Liao, Honglei Liu, Cheng Zhang, Hongchao Guo,* “Phosphine-Catalyzed [4+2] Annulation of Allenoate with Sulfamate-Derived Cyclic Imines: A Reaction Mode Involving γ’-Carbon of α-Substituted Allenoate”, Org. Lett. 2017, 19, 6340–6343.

23. Yang Wu, Chunhao Yuan, Chang Wang, Biming Mao, Hao Jia, Xing Gao, Jianning Liao, Feng Jiang, Leijie Zhou, Qijun Wang, Hongchao Guo,* “Palladium-Catalyzed [5+2] Cycloaddition of Vinyloxiranes with Sulfamate-Derived Cyclic Imines to Construct 1,3-Oxazepine Heterocycles”, Org. Lett. 2017, 19, 6268–6271.

24. Hao Jia, Honglei Liu, Zhenyan Guo, Jiaxing Huang, Hongchao Guo,* “Tandem [3+2] Cycloaddition/1,4-Addition Reaction of Azomethine Ylides and aza-ortho-Quinone Methides for Asymmetric Synthesis of Imidazolidines”, Org. Lett. 2017, 19, 5236−5239.

25. Honglei Liu, Hao Jia, Bo Wang, Yumei Xiao, Hongchao Guo,* “Synthesis of Spirobidihydropyrazole through Double 1,3-Dipolar Cycloaddition of Nitrilimines with Allenoates”, Org. Lett. 2017, 19, 4714−4717.

26. Leijie Zhou, Chunhao Yuan, Cheng Zhang, Lei Zhang, Zhenzhen Gao, Chang Wang, Honglei Liu, Yang Wu, Hongchao Guo,* “Enantioselective Synthesis of Quinazoline-Based Heterocycles through Phosphine-Catalyzed Asymmetric [3+3] Annulation of Morita−Baylis−Hillman Carbonates with Azomethine Imines”, Adv. Synth. Catal. 2017, 359, 2316–2321.

27. Wenjun Yang, Wei Sun, Cheng Zhang, Qijun Wang, Zhenyan Guo, Biming Mao, Jianning Liao, Hongchao Guo,* “Lewis-Base-Catalyzed Asymmetric [3+3] Annulation Reaction of Morita–Baylis–Hillman Carbonates: Enantioselective Synthesis of Spirocyclohexenes”, ACS Catal. 2017, 7, 3142–3146.

28. Chang Wang, Hao Jia, Cheng Zhang, Zhenzhen Gao, Leijie Zhou, Chuanhao Yuan, Yumei Xiao, Hongchao Guo,* “Phosphine-Catalyzed Enantioselective [2+4] Cycloaddition to Synthesize Pyrrolidin-2-one Fused Dihydropyrans Using α-Substituted Allenoates as C2 Synthons”, J. Org. Chem. 2017, 82, 633–641.

29. Chunhao Yuan, Leijie Zhou, Miaoren Xia, Zhanhu Sun, Dongqi Wang, Hongchao Guo,* “Phosphine-Catalyzed Enantioselective [4+3] Annulation of Allenoates with C,N-Cyclic Azomethine Imines: Synthesis of Quinazoline-Based Tricyclic Heterocycles”, Org. Lett. 2016, 18, 5644–5647.

30. Honglei Liu, Yang Liu, Chunhao Yuan, Guo-Peng Wang, Shou-Fei Zhu, Yang Wu, Bo Wang, Zhanhu Sun, Yumei Xiao, Qilin Zhou,* Hongchao Guo,* “Enantioselective Synthesis of Spirobarbiturate-Cyclohexenes through Phosphine-Catalyzed Asymmetric [4+2] Annulation of Barbiturate-Derived Alkenes with Allenoates”, Org. Lett. 2016, 18, 1302−1305.

31. Wenjun Yang, Chunhao Yuan, Yang Liu, Biming Mao, Zhanhu Sun, Hongchao Guo,* “[4+3] Cycloaddition of Phthalazinium Dicyanomethanides with Azoalkenes Formed in Situ: Synthesis of Triazepine Derivatives”, J. Org. Chem. 2016, 81, 7597−7603.

32. Yang Wu, Yang Liu, Wenjun Yang, Honglei Liu, Leijie Zhou, Zhanhu Sun, Hongchao Guo,* Chiral Phosphine-Catalyzed Enantioselective [3+2] Annulation of Morita–Baylis–Hillman Carbonates with Cyclic 1-Azadienes: Synthesis of Functionalized Cyclopentenes, Adv. Synth. Catal. 2016, 358, 3517–3521.

33. Yang Liu, Wenjun Yang, Yang Wu, Biming Mao, Xing Gao, Honglei Liu, Zhanhu Sun, Yumei Xiao, Hongchao Guo,* “Asymmetric Construction of Highly Functionalized Spirobarbiturate-Cyclopentenes through Chiral Phosphine-Catalyzed [3+2] Annulation of Morita-Baylis-Hillman Carbonates with Barbiturate-Derived Alkenes”, Adv. Synth. Catal. 2016, 358, 2867−2872.

34. Zhen Li, Hao Yu, Yang Liu, Leijie Zhou, Zhanhu Sun, Hongchao Guo,* “Phosphane-Catalyzed [3+3] Annulation of C,N-Cyclic Azomethine Imines with Ynones: A Practical Method for Tricyclic Dinitrogen-Fused Heterocycles”, Adv. Synth. Catal. 2016, 358, 1880−1885.

35. Chang Wang, Zhenzhen Gao, Leijie Zhou, Chunhao Yuan, Zhanhu Sun, Yumei Xiao,* Hongchao Guo, “Phosphine-Catalyzed [2+4] Annulation of Allenoates with Thiazolone-Derived Alkenes: Synthesis of Functionalized 6,7-Dihydro-5H-pyrano[2,3-d]thiazoles”, Org. Lett. 2016, 18, 3418−3421.

36. Lei Zhang, Honglei Liu, Guanyu Qiao, Zhanfeng Hou, Yang Liu, Yumei Xiao, Hongchao Guo,* “Phosphine-Catalyzed Highly Enantioselective [3+3] Cycloaddition of Morita-Baylis-Hillman Carbonates with C,N-Cyclic Azomethine Imines”, J. Am. Chem. Soc. 2015, 137, 4316–4319. This article was featured in Chinese Journal of Organic Chemistry 2015, 35, 1380–1382.

37. Chunhao Yuan, Honglei Liu, Zhenzhen Gao, Leijie Zhou, Yalin Feng, Yumei Xiao, Hongchao Guo,* “Cu(I)-Catalyzed Highly Enantioselective [3+3] Cycloaddition between Two Different 1,3-Dipoles, Phthalazinium Dicyanomethanides and Iminoester-Derived Azomethine Ylides”, Org. Lett. 2015, 17, 26−29.

38. Zhenzhen Gao, Chang Wang, Chunhao Yuan, Leijie Zhou, Yumei Xiao,* Hongchao Guo,* “Phosphine-Catalyzed [4+1] Annulation of 2-Tosylaminochalcones with Allenoates: Synthesis of trans-2,3-Disubstitued Indolines”, Chem. Commun. 2015, 51, 12653−12656.

39. Honglei Liu, Chunhao Yuan, Yang Wu, Yumei Xiao, Hongchao Guo,* “Sc(OTf)3-Catalyzed [3+3] Cycloaddition of Cyclopropane 1,1-Diesters with Phthalazinium Dicyanomethanides”, Org. Lett. 2015, 17, 4220−4223.

40. Honglei Liu, Yang Wu, Yan Zhao, Zhen Li, Lei Zhang, Wenjun Yang, Hui Jiang, Chengfeng Jing, Hao Yu, Bo Wang, Yumei Xiao, Hongchao Guo,* “Metal-Catalyzed [6+3] Cycloaddition of Tropone with Azomethine Ylides: A Practical Access to Piperidine-Fused Bicyclic Heterocycles”, J. Am. Chem. Soc. 2014, 136, 2625–2629.

41. Zhen Li, Hao Yu, Honglei Liu, Lei Zhang, Hui Jiang, Bo Wang, Hongchao Guo,* “Phosphine-Catalyzed [3+2] Cycloaddition Reactions of Azomethine Imines with Electron-Deficient Alkenes: A Facile Access to Dinitrogen-Fused Heterocycles”, Chem. Eur. J. 2014, 20, 1731–1736.

42. Zhilin Yang, Hao Yu, Lei Zhang, Hang Wei, Yumei Xiao, Lanzhen Chen, Hongchao Guo,* “PPh3-Catalyzed Ring-Expansion Reactions of Sulfamate-Derived Cyclic Imines with Acetylenedicarboxylates”, Chem. Asian J. 2014, 9, 313–318.

43. Yumei Xiao, Zhanhu Sun, Hongchao Guo,* Ohyun Kwon,* “Chiral Phosphines in Nucleophilic Organocatalysis”, Beilstein J. Org. Chem. 2014, 10, 2089–2121.

44. Hao Yu, Lei Zhang, Zhilin Yang, Zhen Li, Yan Zhao, Yumei Xiao, Hongchao Guo,* “Phosphine-Catalyzed [3+2] Cycloaddition of Sulfamate-Derived Cyclic Imines with Allenoate: Synthesis of Sulfamate-Fused Dihydropyrroles”, J. Org. Chem. 2013, 78, 8427–8436.

45. Hongchao Guo,* Honglei Liu, Fu-Lin Zhu, Risong Na, Hui Jiang, Yang Wu, Lei Zhang,Zhen Li, Hao Yu, Bo Wang, Yumei Xiao, Xiang-Ping Hu,* Min Wang, “Enantioselective Copper-Catalyzed [3+3] Cycloaddition of Azomethine Ylides with Azomethine Imines”, Angew. Chem. Int. Ed. 2013, 52, 12641–12645.

46. Chengfeng Jing, Risong Na, Honglei Liu, Lei Zhang, Jun Liu, Min Wang, Jiangchun Zhong,* Ohyun Kwon, Hongchao Guo*, “Phosphine-Catalyzed [3+2] and [4+3] Annulation Reactions of C,N-Cyclic Azomethine Imines with Allenoates”, Adv. Synth. Catal. 2012, 354, 1023–1034.

47. Risong Na, Chengfeng Jing, Qihai Xu, Hui Jiang, Xi Wu, Jiayan Shi, Jiangchun Zhong, Min Wang, Diego Benitez, Ekaterina Tkatchouk, William A. Goddard, III, Hongchao Guo,* Ohyun Kwon,* “Phosphine-Catalyzed Annulations of Azomethine Imines: Allene-Dependent [3+2], [3+3], [4+3], and [3+2+3] Pathways”, J. Am. Chem. Soc. 2011, 133, 13337–13348

48. Zhiyuan Li, Min Wang, Qinghua Bian, Bing Zheng, Jianyou Mao, Shuoning Li, Shangzhong Liu, Ming-an Wang, Jiangchun Zhong,* Hongchao Guo,* “Highly Enantioselective Addition of Trimethylsilylacetylene to Aldehydes Catalyzed by a Zinc-Amino-Alcohol Complex”, Chem. Eur. J. 2011, 17, 5782–5786.

49. Hongchao Guo, Kuiling Ding, “Indium Tribromide”, Encyclopedia of Reagents for Organic Synthesis, 2011.

50. Hongchao Guo, Kuiling Ding, “Self-Supported Chiral Catalysts”, In Catalytic Methods in Asymmetric Synthesis: Advanced Materials, Techniques, and Applications, First Edition. Michelangelo Gruttadauria, Franceso Giacalone, Eds., John Wiley & Sons, Inc. 2011, Chapter 5, p.257–290.