The design and synthesis of new functional molecules is of central importance to ensure the continued development of new materials, drugs and useful reagents. It is therefore crucial to maintain the development of new reactions and train the next generation of synthetic chemists.
We have been working in the areas of Biomimetic Synthesis and Click Chemistry for a number of years, with the objective of harnessing the power of nature and reactivity to create new transformations and products. In this talk, I will describe our work on the Biomimetic Synthesis of a complex natural product, which led to the development of new reactions and directions using reactive intermediates.1 I will also describe the recent development of some new Click Chemistry inspired transformations from our laboratory, including some novel cycloaddition reactions and amide bond forming SuFEx transformations.2
(1) (a) J. C. Moore, E. S. Davies, D. A. Walsh, P. Sharma, J. E. Moses, Chem. Commun., 2014, 50, 12523; (b) K. J. Powell, L. –C. Han, P. Sharma, J. E. Moses, Org. Lett., 2014, 16, 2158.
(2) (a) C. J. Smedley, A. S. Barrow, C. Spiteri, M. –C. Giel, P. Sharma, J. E. Moses, Chem. Eur. J., 2017, DOI: 10.1002/chem.201701552; (b) S. V. Bhat, D. Robinson, J. E. Moses, P. Sharma, Org. Lett., 2016, 18, 1100; (c) S. Li, P. Wu, J. E. Moses, K. B. Sharpless, Angew. Chem. Int. Ed. 2017, 56, 2903.
John completed a DPhil at Oxford under the supervision of Professor Sir Jack Baldwin, FRS. In 2004, he moved to The Scripps Research Institute, La Jolla, to work with Professor K. B. Sharpless.
His independent research career began at The University of London, School of Pharmacy in 2005, where he was appointed as an RCUK-EPSRC academic fellow in chemical biology/cancer medicinal chemistry. In September 2007, John moved to the University of Nottingham as an Associate Professor in Organic Chemistry, and promoted to Reader in 2012. In 2017 John moved to the University of La Trobe, Melbourne where he was promoted to Professor of Organic Chemistry and is based in the institute of molecular science. The group’s research interests include biomimetic synthesis, click chemistry, anti-cancer drug discovery and chemical biology.